GunOneDown, I have a Ruger .480, but have not loaded anything for it yet. When I do get around to loading for it I'll pm you and maybe we can get together. Mine wont be that fast, but they are pushing 400gr. Hornadies about 1280 fps at the muzzle. I know for a fact it will not breach the vitals plate in a vest strapped to a pine, but I dont think you would want the softball size indention in your chest!
I honestly think that the energy behind that round would crush your chest even with armor. And this is also a handfull.