I've been reloading .40 S&W rounds for 10 years on a Dillon 550B press. My reloading log shows I've loaded over 20,000 rounds in that time and I've fired well over half that ammo, 90% of it through various Glocks, the rest through my Ruger PC4 carbine. As a LEO, I use once fired brass that I get from my department range, which is mostly Glock fired brass.
My point is I reload Glock fired brass to be used primarily in Glock's. I load at regular factory loadings using either 4.5 grains of Tite Group or 6.5 grains of Power Pistol with 180 grain jacketed bullets. I have never, ever had so much as one ammo related malfunction.
Just for my own satisfaction, in 2007 I set aside 200 rounds of factory ammo, Remington and Winchester headstamped. When I shot this ammo I made sure I segregated the brass from the rest so I could keep count of how many times I could reload it. Over a period of several months I fired it through my Glock 23 and reloaded this lot of brass 9 times. After 6 or 7 reloads I had three rounds with split cases at the mouth of the brass, but this could be expected with any round loaded half a dozen times. Not once did I have a bulge, kaboom, or busted case on the bottom end.
I see no significant issue with loading .40 S&W as long as you don't try to make major with the load. If you want a hotrod, get a 10mm, otherwise the .40 is just as safe as any other round to reload. Even if shooting through a Glock.
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