Originally Posted by Rule10b5
Never done penetration tests with 10mm. With other calibers, though, I've found that unless you're using a heavyweight or bonded bullet once you pass a certain velocity threshold, you're a lot less likely to get overpenetration because the bullet expands like mad or just splatters in the target.
I'd run 180grain for full power 10mm loads.
#1: hit your target
#2: get enough penetration
#3: expansion would be nice
#4: with 10mm, you only have to worry about #1