A good safe will not be penetrated by a burglar. Make sure it is bolted down to a solid floor. Unless they are extremely well prepared, and are planning on breaking into a safe (like they know what you have), they're not going to get in.
If you buy a fifty dollar safe, well, all bets are off.
Mount it properly, and it'll be there when you get home!
Of course, a decent security system will do wonders. Fortify your house at all entry points. Etc, etc. Do you live in a bad neighborhood?
G19 G26 G30 Sig 2340 357 Beretta U22 (kid's) Two Saiga 12 Two Draco 7.62x39 "pistols" Colt 6920 Saiga SGL21-94, M92 Krinkov "pistol," PSA Patrol Carbine Saiga 223