I use a holster similar to the crossbreed supertuck. I made it from leather and kydex, and use it for IDPA. My draw is up there with alot of the guys using OWB holsters, so it's definitely fast enough. The draw speed comes from practice and familiarity, though.
Comfort comes from indivual choice, and how you want to carry. I prefer just behind the center-line (8 o'clock, I'm a lefty), above my left rear pocket-ish. Some guys like to carry appendix, in front of their pelvis. It's a very fast draw, and easy to get at if you're seated alot, but you have a gun pointed at your stuff. All day.
I'm not a big dude, 5'10 165 lbs, and I can conceal a full sized glock 17 or 1911 in this position, and wear it all day. It's like wearing a big watch, at first it's weird, but you get used to it, then you feel naked without it.
I don't always rock out with my glock out, but when I do, it's all the way.