This will get the flames going, but I like the PDX1 buck/slug combo for home defense, ie short ranges. It patters nice and tight with poa/poi out of my M4 which has a modified choke. Anything past 15 yds and I would go for a Wolf slug or one of the wonder OO buck loads like the flite control others have posted about. I have also found the cheap winchester walmart value pack buckshot to pattern nicely out of the weapon.
I do have some of the new federal tactical #1 Buck I need to get out and pattern . . .