I used to deer hunt with a .45 Colt and hot handloads in a 10" TC Contender. It's a great combo that worked very well for me.
But I've gotten to busy and lazy in my old age to keep messing with it. I now use a .44 mag 14" barrel on my Contender, drive over to Walmart and I can buy decent ammo easily.
The deer don't seem to notice any difference when hit.
"If your plan is for one year, plant rice.
If your plan is for ten years, plant trees.
If your plan is for one hundred years,
educate children." -- Confucius