I personally have great faith in Honda/Acura reliability. The sacrifice is of course "status" (which is meaningless to me) and "sportiness", which means a lot....
For a daily driver, I'd like comfort that I dont have to bother with. I just dont trust the Audi like I would the Japanese offerings, especially out of warranty...
That being said, maybe you should try an A6, as that is more inline with the other choices, and the interior and power might be more what you want.
You might also want to check out the new Subaru Legacy GT with the 2.5 Turbo motor. Fairly quick, AWD, with a very nice interior, similar pricing to the Acura, just a thought.