I'd say it depends on what you call a rifle rd.
There are 10mm loads that match the 223 softpoint in effectiveness, and the 223 has an awesome stopping record. Nobody is stuck with the silly fmj load. The military "ball" bullet (in all calibers) is uniformly acknowledged as being inhumane for taking deer, because it usually lets them run for 100 yds or more after being chest hit by such a load.
If you want 2000 ft lbs of impact energy, then the 308 is not a "real rifle rd" beyond 200 yds. In fact, with some loads, in an 18" barrel, it's not up to delivering such performance at 100 yds.
It's not that tough to create a pocket pistol load that outperfoms the 600 ft lb lead flat point (1200 fps) 44-40 bullet that "won the west". Such bullets waste a fair amount of power on the far side of the man who is shot with them. The same thing goes for the 900 ft lbs of the .30 Carbine, yet such rifles have stopped many thousands of men with a single chest hit.
So the issue is:"Can the pistol be loaded in such a way as to get its stopping probability way up there (ie, 19 stops out of 20 shootings) with a single chest hit?" The answer is yes, it can be done. It does, however, take some special bullets, and large cased, high pressure rds like the 10mm, in 5" barrels.