[SouthernBoy26]

I am mac guy, trying to help out my buddy. I have never messed with Vista, but his Laptop will not open any programs. Not even windows explorer will open. Just logged on my network and it is stuck on a spinning blue orb. Nothing will launch? Any help on what to do would be great!

[Sgt. Schultz]

What was he doing when the laptop started acting up?

I'd start the system in safe mode and scan it using Malewarebytes ...

http://www.majorgeeks.com/downloadge...d909666f809b26

and the latest update ...
http://mbam.malwarebytes.org/database/mbam-rules.exe

... copy both to a USB drive and install, then update and do a full scan.