Lots of MKIII 22/45 shooters over on RFC have modified the molded frames on their Rugers to accept 1911 grips.
I used Ed Brown Stainless-Steel 1911 Grip Screws and Grip Screw Bushings with the Hogue Rubber Finger Groove 1911 Grips.
Other modifications include:
Clark Custom Guns Steel Ruger Trigger
Volquartsen Custom Target Sear
Hand honed Factory Hammer
HiViz Fiber Optic Front Sight