If you are using loads that are well off the top end, swapping brand of primer will have little affect on pressures. Where yo can get into trouble is w/ a max load & a slightly hotter primer. I've verifed this many times w/ a chronograph.
"Given adequate penetration, a larger diameter bullet will have an edge in wounding effectiveness. It will damage a blood vessel the smaller projectile barely misses. The larger permanent cavity may lead to faster blood loss. Although such an edge clearly exists, its significance cannot be quantified".