AK gave good advice.
Let me add this. You can shoot all the lead you want out of a Ruger. I been doing it for over 40 years. 98% of all my loads (hand loads and shooting) are with Hard Cast lead from Hunters Supply, Lead Heads, or Beartooth bullets.
With the "NEW" Vaquero, you will have to shoot loads
not over 1050fps,
about 27000 psi. It is NOT as strong as the "OLD" style Ruger Vaquero's I carry and will not take the added pressures. It was designed for the cowboy action shooting crowd, and for , as I said, NO more than 1050fps. So
Do not buy HOT laods for it, and
do not reload HOT for it.
You can run up to 300gr bullets in it, both cast and JHP's. been doing it for years in the Vaquero's. You'll be fine.
Just stay within the 1050fps MAX range and you ar perfectly fine....
In fact, I just bought a Ruger 44 Special Flat Top. It is the same with this. I cannot shoot as hot a load through this
new model, as I can from the old Vaquero or SBH 44 mag
with 44 specials in them. They are just made on a smaller lighter frame, and cylinder walls are not as thick.
You will love your new gun if you stay within the 1050fps limit.
To encourage you. A 275 gr bullet at 1,000 fps or a 250gr at 1,000fps will kill Elk with a well placed lung shot using hard cast bullets from your gun out at 50yds. So think about your gun this way.
Enjoy !
CM