As noted, both, since you are running the top end of WST. In low to midrange pressure leves, not as critical, but at the top end, everything matters. Drop the load back 5% & work it back up.
"Given adequate penetration, a larger diameter bullet will have an edge in wounding effectiveness. It will damage a blood vessel the smaller projectile barely misses. The larger permanent cavity may lead to faster blood loss. Although such an edge clearly exists, its significance cannot be quantified".