Just depends on which grip you like best, or if you like all metal or polymer frame. I've owned both and like both so it doesn't matter to me. I'll say this though. I had a 22/45, with a 4" bull barrel that I mounted a cheap BSA red dot scope on that at 21 feet was SCAREY accurate. That thing would shoot one hole groups all day long with cheap bulk pack ammo. I'm sure it would have at longer ranges too, but my range only has 7 yard lines.
Let me offer this advice. Look used. I picked up an old Ruger Standard, with a 6" barrel, and fixed sights, with box and papers yesterday for less than $200.00.
For God so loved the world that He gave His only begotten Son, that whoever believes in Him would not perish, but have everlasting life.
John 3:16 (NKJV)